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Research
Exposure to biodiesel exhaust is less harmful than exposure to mineral diesel exhaust on blood-brain barrier integrity in a murine modelEmerging data suggest that air pollution is a persistent source of neuroinflammation, reactive oxygen species, and neuropathology that contributes to central nervous system disorders. Previous research using animal models has shown that exposure to diesel exhaust causes considerable disruption of the blood-brain barrier, leading to marked neuroinflammation.
Research
A pilot study into assessing the danger of heated-tobacco-productsAlexander Anthony Dr Katherine Larcombe Kicic Landwehr BScEnv (Hons) PhD BSc (Hons) PhD BSc(Hons) Honorary Research Fellow Rothwell Family Fellow;
News & Events
Tips for protecting your baby in the summer heatPaediatrician Dr Lana Bell shares her top tips for keeping your baby or toddler cool, well-hydrated and protected as the temperature soars.
Research
Airway-associated adipose tissue accumulation is increased in a kisspeptin receptor knockout mouse modelAirway-associated adipose tissue increases with body mass index and is a local source of pro-inflammatory adipokines that may contribute to airway pathology in asthma co-existing with obesity. Genetic susceptibility to airway adiposity was considered in the present study through kisspeptin/kisspeptin receptor signalling, known to modulate systemic adiposity and potentially drive airway remodelling.
Research
The airway smooth muscle layer is structurally abnormal in low birth weight infants: implications for obstructive diseaseCitation: Wang KCW, Elliot JG, Saglani S, et al. The airway smooth muscle layer is structurally abnormal in low birth weight infants: implications
Research
RISING STARS: The heat is on: how does heat exposure cause pregnancy complications?The incidence and severity of heatwaves are increasing globally with concomitant health complications. Pregnancy is a critical time in the life course at risk of adverse health outcomes due to heat exposure. Dynamic physiological adaptations, which include altered thermoregulatory pathways, occur in pregnancy.
News & Events
Prospective Student EveningStudents met ORIGINS team at the recent Prospective Student Evening at Telethon Kids Institute.
Research
An infant mouse model of influenza-driven nontypeable Haemophilus influenzae colonization and acute otitis media suitable for preclinical testing of novel therapiesNontypeable Haemophilus influenzae (NTHi) is a major otitis media (OM) pathogen, with colonization a prerequisite for disease development. Most acute OM is in children <5 years old, with recurrent and chronic OM impacting hearing and learning. Therapies to prevent NTHi colonization and/or disease are needed, especially for young children. Respiratory viruses are implicated in driving the development of bacterial OM in children.
Research
Defective aeroallergen surveillance by airway mucosal dendritic cells as a determinant of riskA hallmark of atopic asthma is development of chronic airways hyper-responsiveness (AHR) that persists in the face of ongoing exposure to perennial...
Research
Factors influencing the assessment of lung function in mice with influenza-induced lung diseaseThe constant-phase model (CPM) is commonly fit to respiratory system input impedance (Z rs) to estimate lung mechanics.
Research
Early life arsenic exposure and acute and long-term responses to influenza A infection in miceExposure to arsenic in early life has been shown to increase the rate of respiratory infections during infancy, reduce childhood lung function, and increase...
News & Events
Hong Kong researcher highlights importance of nature for children during Joondalup Health Campus visitJoondalup Health Campus welcomed international researcher Dr Tanja Sobko to share her research on the link between mental health and time spent in nature.
News & Events
Early ORIGINS: Disease prevention starts with the early yearsThe Joondalup Health Campus and The Kids are investigating how childhood and adult-onset diseases can be prevented during foetal development and in the early years of life.
Accessing the ORIGINS cohort, database or biological samples involves a process of review and approval.
ORIGINS is fortunate to have a small passionate and dedicated group of longstanding volunteers.
The ORIGINS Biobank is collecting biological samples from participant families at 10 timepoints between the time of pregnancy and the child turning five years of age.
ORIGINS is collecting physiological, biological and clinical data from the mother, partner/father and child at numerous points to track development and change.
A list of organisations that currently collaborate with ORIGINS.