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Research
Early life arsenic exposure and acute and long-term responses to influenza A infection in miceExposure to arsenic in early life has been shown to increase the rate of respiratory infections during infancy, reduce childhood lung function, and increase...
Research
Factors influencing the assessment of lung function in mice with influenza-induced lung diseaseThe constant-phase model (CPM) is commonly fit to respiratory system input impedance (Z rs) to estimate lung mechanics.
Research
Defective aeroallergen surveillance by airway mucosal dendritic cells as a determinant of riskA hallmark of atopic asthma is development of chronic airways hyper-responsiveness (AHR) that persists in the face of ongoing exposure to perennial...
Research
The effects of e-cigarette use on asthma severity in adult BALB/c miceElectronic cigarettes (e-cigarettes) are often perceived to be a less harmful alternative to tobacco cigarettes. Potentially due to this perception, they are used by people with pre-existing respiratory conditions, such as asthma, who otherwise would not smoke. Despite this, there are few studies exploring the health effects of e-cigarette use on pre-existing asthma.
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New The Kids Board membersWe are delighted to announce two outstanding appointments to our Board of Directors. Joining the Board are Fiona Drummond and Jane Muirsmith.
Research
In utero and early-life nitrate in drinking water impacts lung function of weanling ratsConsumption of nitrate in drinking water has previously been associated with a range of adverse health effects, including methemoglobinemia and potentially cancer. In animal models, it has been shown to impact respiratory structure and function, however, there is a paucity of data of the effects of in utero exposure on the respiratory health of offspring.
Research
Comment on Karthikeyan et al. Concordance between In Vitro and In Vivo Relative Toxic Potencies of Diesel Exhaust Particles from Different Biodiesel Blends. Toxics 2024, 12, 290Dr Katherine Alexander Landwehr Larcombe BSc(Hons) BScEnv (Hons) PhD Senior Research Officer Honorary Research Fellow Katherine.landwehr@
Research
Exposure to biodiesel exhaust is less harmful than exposure to mineral diesel exhaust on blood-brain barrier integrity in a murine modelEmerging data suggest that air pollution is a persistent source of neuroinflammation, reactive oxygen species, and neuropathology that contributes to central nervous system disorders. Previous research using animal models has shown that exposure to diesel exhaust causes considerable disruption of the blood-brain barrier, leading to marked neuroinflammation.
Research
An infant mouse model of influenza-driven nontypeable Haemophilus influenzae colonization and acute otitis media suitable for preclinical testing of novel therapiesNontypeable Haemophilus influenzae (NTHi) is a major otitis media (OM) pathogen, with colonization a prerequisite for disease development. Most acute OM is in children <5 years old, with recurrent and chronic OM impacting hearing and learning. Therapies to prevent NTHi colonization and/or disease are needed, especially for young children. Respiratory viruses are implicated in driving the development of bacterial OM in children.
News & Events
The Impact of Poverty - interview with Louise GiolittoPoverty invades every aspect of a child’s life and, as a growing body of research tells us, affects physical and mental wellbeing as well as future opportunitie
Research
The airway smooth muscle layer is structurally abnormal in low birth weight infants: implications for obstructive diseaseCitation: Wang KCW, Elliot JG, Saglani S, et al. The airway smooth muscle layer is structurally abnormal in low birth weight infants: implications
Research
Airway-associated adipose tissue accumulation is increased in a kisspeptin receptor knockout mouse modelAirway-associated adipose tissue increases with body mass index and is a local source of pro-inflammatory adipokines that may contribute to airway pathology in asthma co-existing with obesity. Genetic susceptibility to airway adiposity was considered in the present study through kisspeptin/kisspeptin receptor signalling, known to modulate systemic adiposity and potentially drive airway remodelling.
News & Events
Urgent action needed to stop 500 preventable deathsA new report predicts rheumatic heart disease (RHD) will lead to over 500 preventable deaths and cost the Australian health system $317 million by 2031 if no further action to tackle the disease is taken.
News & Events
Bupa pledges half a million dollars to end rheumatic heart diseaseResearchers will extend a unique community-led project to end rheumatic heart disease in Aboriginal communities, thanks to nearly half a million dollars in funding from Bupa.
News & Events
New report to shape early years services in MidlandA new report on families with 0-4 year olds in the Midland area aims to help shape development of the sector and ensure parents are better placed to access support in their efforts to ensure the healthy development of their babies and toddlers.
News & Events
The Kids researcher awarded Research Translation Projects grantA new research project aims to demonstrate how influenza vaccination in children could be a highly cost-effective health care intervention in Australia.
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Harvard Professor captivates at Annual Community LectureProfessor Bloom used his time to make a powerful case for the idea that 'healthier means wealthier' at the The Kids Annual Community Lecture for 2017
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Cholesterol and blood pressure drugs help teens with diabetesThe study involved screening young people to learn more about the development of long-term kidney, eye and cardiovascular complications in adolescents with T1D.
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CoLab scholarship to help drive better access to support servicesCurtin University researcher Belinda Cuomo is one of the first recipients of a CoLab Top-Up Scholarship.
News & Events
Long-term The Kids Research Institute Australia researchers honoured by prestigious AcademyProfessors Carol Bower & Steve Zubrick have been inducted as new Fellows to the prestigious Australian Academy of Health and Medical Sciences.