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Impaired T cell proliferation by ex vivo BET-inhibition impedes adoptive immunotherapy in a murine melanoma modelWe established a pipeline to assess the effects of epigenetic modifiers on CD8+ T cell proliferation, differentiation, and efficacy in a preclinical melanoma model
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Viral respiratory infections and the oropharyngeal bacterial microbiota in acutely wheezing childrenBacterial airway microbiome is highly variable in early life and its role in wheeze remains less clear than viral influences
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A framework for the management of the pediatric airwayA simple, time critical, and pediatric-specific airway management approach will help to reduce airway-related pediatric morbidity and mortality
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Using pneumococcal carriage studies to monitor vaccine impact in low- and middle-income countriesWe review the role of pneumococcal carriage studies for the evaluation of PCVs in LMICs and discuss optimal methods for conducting these studies
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Effectiveness of rotavirus vaccines in an Australian population: A case-control studyRV1 and RV5 were both effective in preventing laboratory confirmed and notified rotavirus infections among children aged <5 years
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Meta-taxonomic analysis of prokaryotic and eukaryotic gut flora in stool samples from visceral leishmaniasis cases and endemic controls in Bihar State IndiaWe evaluate a meta-taxonomic approach to determine the composition of prokaryotic and eukaryotic gut microflora using sequencing of 16S RNA and 18S rRNA
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Chronic wet cough in Aboriginal children: It's not just a coughResults highlight the need for a culturally appropriate information and education of the importance of chronic wet cough in children
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In Epigenomic Studies, Including Cell-Type Adjustments in Regression Models Can Introduce Multicollinearity, Resulting in Apparent Reversal of Direction of AssociationWhere cell types are highly correlated with other covariates in regression models, the statistical assumption of no multicollinearity may be violated
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Maternal Smoking During Pregnancy Induces Epigenetic Changes Into Adolescence, Independent of Postnatal Smoke Exposure and Is Associated With Cardiometabolic RiskThis study demonstrates a critical timing of cigarette smoke exposure over the life course for establishing persistent changes in DNA methylation into adolescence
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Glutathione S-Transferase Genotype Protects against in Utero Tobacco-linked Lung Function DeficitsCertain glutathione S-transferase genotypes may have protective effects against the long-term deficits in lung function associated with in utero tobacco exposure