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Long-term exposure of mice to 890 ppm atmospheric CO2 alters growth trajectories and elicits hyperactive behaviours in young adulthoodAtmospheric carbon dioxide (CO2) levels are currently at 418 parts per million (ppm), and by 2100 may exceed 900 ppm. The biological effects of lifetime exposure to CO2 at these levels is unknown. Previously we have shown that mouse lung function is altered by long-term exposure to 890 ppm CO2. Here, we assess the broader systemic physiological responses to this exposure.
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Editorial overview: The physiology of the diseased lungAlexander Larcombe BScEnv (Hons) PhD Head, Respiratory Environmental Health Team Leader, Respiratory Environmental Health Associate Professor
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In Vitro primary human airway epithelial whole exhaust exposureThe method outlined in this article is a customization of the whole exhaust exposure method generated by Mullins et al. (2016) using reprogrammed primary human airway epithelial cells as described by Martinovich et al. (2017). It has been used successfully to generate recently published data (Landwehr et al. 2021). The goal was to generate an exhaust exposure model where exhaust is collected from a modern engine, real-world exhaust concentrations are used and relevant tissues exposed to assess the effects of multiple biodiesel exposures.
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Confounding effects of gavage in mice: Impaired respiratory structure and functionIt is therefore clear that gavage can have significant impacts on experimental animals in terms of their stress response and overall morbidity and mortality
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Emerging issues in the Pacific BasinThis review provides a snapshot of some key environmental health issues that will provide ongoing challenges for the Pacific Basin region in the coming decades
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The mechanism of deep inspiration-induced bronchoprotection: Evidence from a mouse modelIn healthy individuals, deep inspirations (DIs) taken prior to a bronchial challenge reduce the bronchoconstrictor response, which is termed...
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In utero exposure to low dose arsenic via drinking water impairs early life lung mechanics in miceAll alterations to lung mechanics following in utero arsenic exposure were recovered by adulthood.
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Adipose tissue in the small airways: How much is enough to drive functional changes?Obesity is a contributing factor to asthma severity; while it has long been understood that obesity is related to greater asthma burden, the mechanisms though which this occurs have not been fully elucidated. One common explanation is that obesity mechanically reduces lung volume through accumulation of adipose tissue external to the thoracic cavity.
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Investigating the effects of macrolides on excessive synthesis and secretion of airway mucins using novel ex vivo and in vivo approachesAlexander Larcombe BScEnv (Hons) PhD Head, Respiratory Environmental Health Team Leader, Respiratory Environmental Health Associate Professor
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Lung function in a model of a paediatric metabolic diseaseAlexander Larcombe BScEnv (Hons) PhD Head, Respiratory Environmental Health Team Leader, Respiratory Environmental Health Associate Professor