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An in silico pipeline to filter the Toxoplasma gondii proteome for proteins that could traffic to the host cell nucleus and influence host cell epigenetic regulationTo identify genes with putative epigenetic functions, we developed an in silico pipeline to interrogate the T. gondii proteome of 8313 proteins
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Genetic and environmental factors in the aetiology of hypospadiasThe increasing use of assisted reproductive techniques and hormonal manipulation during pregnancy may have been associated with an apparent rise in the...
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A Method to Exploit the Structure of Genetic Ancestry Space to Enhance Case-Control StudiesThese results highlight how UNICORN can enable reliable, powerful, and convenient genetic association analyses without access to the individual-level data
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Translating aboriginal genomics — four letters closing the gapEstablishing a genomic reference for Australian Aboriginal populations
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Folate pathway gene polymorphisms, maternal folic acid use, and risk of childhood acute lymphoblastic leukaemiaSeveral studies suggest that maternal folic acid supplementation before or during pregnancy protects against childhood acute lymphoblastic leukaemia (ALL).
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P2X7 receptor-mediated killing of an intracellular parasite, Toxoplasma gondii, by human and murine macrophagesThe P2X7R is highly expressed on the macrophage cell surface, and activation of infected cells by extracellular ATP has been shown to kill intracellular bacte
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Genome-wide association analysis identifies 13 new risk loci for schizophreniaCommon genetic variation has an important role in the etiology of schizophrenia, and larger studies will allow more detailed understanding of this disorder.
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Comparative analysis of the full genome of Helicobacter pylori isolate sahul64 identifies genes of high divergenceGenome sequence of Sahul64, an H. pylori strain isolated from an indigenous Australian
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FBXO11, a regulator of the TGFΒ pathway, is associated with severe otitis media in Western Australian childrenOtitis media (OM) is a common childhood disease characterised by middle ear inflammation following infection
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Genetic susceptibility to otitis media in childhoodReviewed in this article these studies have identified positive association at 21 genes with association at five of these replicated in independent populations.