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Research
PGE2 pulsing of murine bone marrow cells reduces migration of daughter monocytes/macrophages in vitro and in vivoOur results reveal long-lasting changes to progenitor cells of monocytes/macrophages by a 2-hour dimethyl PGE2 pulse that, in turn, limits the migration of their daughter cells to chemoattractants and inflammatory mediators.
Research
Use of linked administrative and laboratory data to confirm that serum 25(OH)D levels in pregnant women can be predicted from satellite estimates of ultraviolet radiationSerum 25 hydroxyvitamin D [25(OH)D] levels of pregnant women have been linked to various health outcomes in their offspring. Satellite-derived ultraviolet radiation (UVR) data have been used as a proxy for 25(OH)D levels, as individual-level cohort studies are time-consuming, costly and only feasible for common outcomes.
Research
Gene regulation by 1,25-dihydroxyvitamin D3 in CD4+CD25+ cells is enabled by IL-2Vitamin D may be responsible for reducing the development and severity of autoimmune and allergic diseases. Topically applied 1,25-dihydroxyvitamin D(3) (1,25(O
Research
Immune-modifying properties of topical vitamin D: Focus on dendritic cells and T cellsTopical creams containing the active form of vitamin D (1,25-dihydroxyvitamin D3; 1,25(OH)2D3) or analogues of this compound are currently used with some succes
Research
Vitamin D deficiency causes deficits in lung function and alters lung structureThe prevalence of vitamin D deficiency is increasing and has been linked to obstructive lung diseases including asthma and chronic obstructive pulmonary disease
News & Events
Vitamin D deficiency linked to childhood asthmaResearchers at The Kids Research Institute Australia have found children with vitamin D deficiency are more likely to develop asthma.
News & Events
UV offers new hope in fight against MSPeople at risk of developing multiple sclerosis (MS) have been offered a beacon of hope thanks to research into UV exposure.
Research
Immunobiology & Immunotherapeutic ProgramListed are The Kids Research Institute Australia research teams involved in our Immunity and Inflammation Program. This program sits under the Early Environment research theme.
Research
More Than Effects in Skin: Ultraviolet Radiation-Induced Changes in Immune Cells in Human BloodCells of the skin and circulation are in constant two-way communication. Following exposure of humans to sunlight or to phototherapy, there are alterations in the number, phenotype and function of circulating blood cells.
Research
Vitamin D metabolites are lower with active Crohn’s disease and spontaneously recover with development of remissionWe aimed to characterise vitamin D metabolism in a cohort of patients with active and inactive Crohn’s disease