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Research
Women Migrants in Western Australia: Case Studies of Resilience and EmpowermentWe propose that women migrants, through alliances and collaboration, cross borders of learning and work towards generating change and transformation
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Machine learning and clinical epigenetics: a review of challenges for diagnosis and classificationWe now have a growing number of epigenetic alterations in disease, and this offers a chance to increase sensitivity and specificity of future diagnostics and therapies
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Small-molecule screen reveals synergy of cell cycle checkpoint kinase inhibitors with DNA-damaging chemotherapies in medulloblastomaMedulloblastoma (MB) consists of four core molecular subgroups with distinct clinical features and prognoses. Treatment consists of surgery, followed by radiotherapy and cytotoxic chemotherapy. Despite this intensive approach, outcome remains dismal for patients with certain subtypes of MB, namely, MYC-amplified Group 3 and TP53-mutated SHH. Using high-throughput assays, six human MB cell lines were screened against a library of 3208 unique compounds. We identified 45 effective compounds from the screen and found that cell cycle checkpoint kinase (CHK1/2) inhibition synergistically enhanced the cytotoxic activity of clinically used chemotherapeutics cyclophosphamide, cisplatin, and gemcitabine.
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Overcoming the challenges of caring for a child with foetal alcohol spectrum disorder: a Pilbara community perspectiveThe caregivers in this study have gained valuable knowledge and wisdom through caring for a child with FASD
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Upper Airway Pathology Contributes to Respiratory Symptoms in Children Born Very PretermThe upper airway may play a role in the respiratory symptoms experienced by some very preterm children and should be considered by clinicians
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Effect of Fluoxetine on Obsessive-Compulsive Behaviors in Children and Adolescents With Autism Spectrum Disorders: A Randomized Clinical TrialTreatment with fluoxetine compared with placebo resulted in significantly lower scores for obsessive-compulsive behaviors at 16 weeks
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Hospitalisations for maternal assault are associated with increased risk of child protection involvementChild maltreatment allegation is common in children following a maternal hospitalisation for assault
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Assessing the quality, efficiency and usefulness of the Western Australian population-based Intellectual Disability Exploring Answers (IDEA) surveillance systemThe IDEA system is a valuable resource to address the needs of people living with intellectual disability
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Soy Biodiesel Exhaust is More Toxic than Mineral Diesel Exhaust in Primary Human Airway Epithelial CellsExposure to biodiesel exhaust resulted in significantly greater cell death and a greater release of immune mediators compared to both air controls and ULSD exhaust
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Prednisolone Versus Dexamethasone for Croup: a Randomized Controlled TrialThe type of oral steroid seems to have no clinically significant impact on efficacy, both acutely and during the week after treatment