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To investigate the immune capabilities of peripheral tissue DCs generated in vivo from the BM of UV-irradiated mice, chimeric mice were established.
Injection of BM-differentiated DCs from nonchimeric mice restored the reduced immune responses of PGE2-chimeric mice.
Our results identify a pretreatment tumor microenvironment that predicts response to immune checkpoint blockade, which can be therapeutically attained
These findings suggest that tumor cells employ multiple epigenetic and genetic mechanisms to evade immune control
Our findings provide insight into the immune cell populations important for maintaining long-term tumour dormancy in peripheral tissues
In this review, we discuss the different subsets of tumor-infiltrating dendritic cells and their role in anti-tumor immunity
Our data demonstrate that CD8+XCR1neg DCs possess a unique pattern of endocytic receptors and a restricted TLR profile that is particularly enriched for TLR5
Our results show that TRM cells have a fundamental role in the surveillance of subclinical melanomas in the skin by maintaining cancer-immune equilibrium
Our findings present a novel mouse model for glioma demonstrating that the PI3K pathway is important for initiation of tumorigenesis
Data indicate a role for Interferonβ in linking viral infection and allergy