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The study of the respiratory microbiota has revealed that the lungs of healthy and diseased individuals harbour distinct microbial communities. Imbalances in these communities can contribute to the pathogenesis of lung disease. How these imbalances occur and establish is largely unknown. This review is focused on the genetically inherited condition of Cystic Fibrosis.
Pulmonary exacerbations in cystic fibrosis are characterized by airway inflammation and may cause irreversible lung damage. Early identification of such exacerbations may facilitate early initiation of treatment, thereby potentially reducing long-term morbidity. Research question: Is it possible to predict pulmonary exacerbations in children with cystic fibrosis, using inflammatory markers obtained from BAL fluid?
The Kids researchers have been awarded over $3.4 million for a new trial to pioneer improved ways for managing cystic fibrosis (‘CF’).
We tested the hypothesis that treatment of CF epithelial cells with ivacaftor (Iva) or ivacaftor/lumacaftor (Iva/Lum) would improve control of rhinovirus infection.
Lung inflammation and simulated airway resistance in infants with cystic fibrosis Cystic fibrosis (CF) is characterized by small airway disease; but
Phagocyte extracellular traps in children with neutrophilic airway inflammation Childhood lung infection is often associated with prominent
Differential cell counts using center-point networks achieves human-level accuracy and efficiency over segmentation Differential cell counts is a
Pseudomonas aeruginosa Resistance to Bacteriophages and Its Prevention by Strategic Therapeutic Cocktail Formulation Antimicrobial resistance poses a
Overcoming Challenges to Make Bacteriophage Therapy Standard Clinical Treatment Practice for Cystic Fibrosis Individuals with cystic fibrosis (CF)
An adapted novel flow cytometry methodology to delineate types of cell death in airway epithelial cells Cystic fibrosis (CF) lung disease is