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The prevalence of impetigo and pharyngitis - which are both superficial group A streptococcus (GAS) infections that precede acute rheumatic fever - is poorly defined. Guidelines recommend the early diagnosis of both infections to prevent ARF; however, screening to enable the concurrent detection of these infections in high-risk populations has rarely been performed.
This paper reports on treatment, and preventing infection in close contact, of invasive group A streptococcal (iGAS) using the antibiotic clindamycin and...
We propose that hydroxychloroquine could be repurposed to reduce the risk of rheumatic heart disease after acute rheumatic fever
The rates of RHD in Timor-Leste are among the highest in the world, and prevalence is higher among girls than boys
The authors present a variety of pressing clinical research questions on optimal RHD prevention and advanced care
Quantification of the disease burden caused by different risks informs prevention by providing an account of health loss different to that provided by a...
This review outlines a clinical development strategy detailing the phases of development required for registration of a candidate Group A streptococci vaccin
Echocardiographic screening for rheumatic heart disease is cost-effective in our context
Rheumatic heart disease (RHD) after group A streptococcus (GAS) infections is heritable and prevalent in Indigenous populations. Molecular mimicry between human and GAS proteins triggers proinflammatory cardiac valve-reactive T cells.
Jonathan Carapetis AM AM MBBS FRACP FAFPHM PhD FAHMS Executive Director; Co-Head, Strep A Translation; Co-Founder of REACH 08 6319 1000 contact@