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Copeptin Kinetics and Its Relationship to Osmolality During Rehydration for Diabetic Ketoacidosis in ChildrenCopeptin is a surrogate marker for arginine vasopressin (AVP) release in response to hyperosmolal stimuli such as diabetic ketoacidosis (DKA). The objective of this work is to characterize kinetics of copeptin and osmolality, and their dynamic relationship during rehydration and insulin therapy in children with type 1 diabetes (T1D) and DKA.
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T-Cell Expression and Release of Kidney Injury Molecule-1 in Response to Glucose Variations Initiates Kidney Injury in Early DiabetesHalf of the mortality in diabetes is seen in individuals <50 years of age and commonly predicted by the early onset of diabetic kidney disease (DKD). In type 1 diabetes, increased urinary albumin-to-creatinine ratio (uACR) during adolescence defines this risk, but the pathological factors responsible remain unknown.
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Demographic and clinical characteristics of a population-based pediatric cohort of type 1 and type 2 diabetes in Western Australia (1999-2019)To determine demographic and clinical characteristics of youth diagnosed with Type 1 (T1D) or Type 2 (T2D) diabetes aged
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A Cost-Effectiveness Analysis of Sensor-Augmented Insulin Pump Therapy and Automated Insulin Suspension versus Standard Pump TherapyA clinical trial-based economic evaluation was performed in which the net costs and effectiveness of the two treatment modalities were calculated and...
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New insights into diabetes in Australian Aboriginal populationThe Kids Research Institute Australia have shown that genetic variations that influence BMI and diabetes are similar to those in non-Aboriginal populations.
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Safety and efficacy of the predictive low glucose management system in the prevention of hypoglycaemiaThe predictive low glucose management system was evaluated in in-clinic studies, and has informed a larger home trial to study its efficacy and safety
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School performance in children with type 1 diabetes: A contemporary population-based studyType 1 diabetes is not associated with a significant decrement in school performance, as assessed by NAPLAN
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Effect of exercise intensity on glucose requirements to maintain euglycemia during exercise in type 1 diabetesInverted-U relationship between exercise intensity and glucose requirement
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Perceived stress in mothers of children with and without islet and coeliac autoimmunity in the ENDIA studyWe aimed to assess perceived stress and influencing factors in mothers with children at risk of type 1 diabetes and coeliac disease who did, or did not, develop islet autoantibodies or coeliac autoantibodies by 4 years of age.
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Understanding Diabetes: Early environmental determinants of pancreatic islet autoimmunity: a pregnancy to early life cohort study in children at risk of type 1 diabetesThis study is looking for the causes of type 1 diabetes, so that we can find ways to prevent it. We will follow many women around Australia during pregnancy until early childhood, looking at the child's birth, environment and genes.