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Influence of gestational age on dead space and alveolar ventilation in preterm infants ventilated with volume guaranteeVentilated preterm infant lungs are vulnerable to overdistension and underinflation.
Research
Persistent and compartmentalised disruption of dendritic cell subpopulations in the lung following influenza A virus infectionImmunological homeostasis in the respiratory tract is thought to require balanced interactions between networks of dendritic cell (DC) subsets in lung...
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Route of exposure alters inflammation and lung function responses to diesel exhaustIn this study, we compared the physiological consequences of short-term exposure to diesel exhaust via inhalation to those due to exposure to the same diesel...
Research
Rhinovirus exacerbates house-dust-mite induced lung disease in adult miceIn this study, we combined human-rhinovirus infection with a clinically relevant mouse model of aero-allergen exposure using house-dust-mite in an attempt to...
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The concentration of iron in real-world geogenic PM10 is associated with increased inflammation and deficits in lung function in miceMineral dusts in the occupational setting are associated with poor lung health, however very little is known about the impact of heterogeneous community...
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The influence of moving walls on respiratory aerosol deposition modellingThis work initially examines particle deposition in a Weibull-type geometry, comparing traditional computational fluid dynamics approaches with a novel...
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In utero exposure to low dose arsenic via drinking water impairs early life lung mechanics in miceAll alterations to lung mechanics following in utero arsenic exposure were recovered by adulthood.
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The mechanism of deep inspiration-induced bronchoprotection: Evidence from a mouse modelIn healthy individuals, deep inspirations (DIs) taken prior to a bronchial challenge reduce the bronchoconstrictor response, which is termed...
Research
Acute diesel exhaust particle exposure increases viral titre and inflammation associated with existing influenzaExposure to diesel exhaust particles (DEP) is thought to exacerbate many pre-existing respiratory diseases.
Research
Sensitizing and Th2 Adjuvant Activity of Cysteine Protease AllergensHere, we report on a model that does not use Th2-skewing adjuvants and yet achieves sensitization solely via the nasal mucosa.