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Respiratory toxicology of e-cigarettes: effect of vapours on lung function and inflammation

Electronic cigarettes (ECs) have been rapidly gaining ground on conventional cigarettes due to their efficiency in ceasing or reducing tobacco consumption,...

Persistent and compartmentalised disruption of dendritic cell subpopulations in the lung following influenza A virus infection

Immunological homeostasis in the respiratory tract is thought to require balanced interactions between networks of dendritic cell (DC) subsets in lung...

Route of exposure alters inflammation and lung function responses to diesel exhaust

In this study, we compared the physiological consequences of short-term exposure to diesel exhaust via inhalation to those due to exposure to the same diesel...

Rhinovirus exacerbates house-dust-mite induced lung disease in adult mice

In this study, we combined human-rhinovirus infection with a clinically relevant mouse model of aero-allergen exposure using house-dust-mite in an attempt to...

The concentration of iron in real-world geogenic PM10 is associated with increased inflammation and deficits in lung function in mice

Mineral dusts in the occupational setting are associated with poor lung health, however very little is known about the impact of heterogeneous community...

The influence of moving walls on respiratory aerosol deposition modelling

This work initially examines particle deposition in a Weibull-type geometry, comparing traditional computational fluid dynamics approaches with a novel...

In utero exposure to low dose arsenic via drinking water impairs early life lung mechanics in mice

All alterations to lung mechanics following in utero arsenic exposure were recovered by adulthood.

Carbon dioxide overload, detected in human blood, suggests a potentially toxic atmosphere within 50 years

Anthropogenic activities are increasing the amount of carbon dioxide (CO2) in the atmosphere. There is mounting experimental evidence that lifetime exposure to these increasing atmospheric CO2 levels can negatively impact the normal physiology of organisms. However, directly assessing this in humans is very difficult. 

Proteomic Insights into Intrauterine Growth Restriction and Its Role in Asthma Pathogenesis

Intrauterine growth restriction (IUGR) increases risk of developing respiratory diseases such as asthma later in life. This study aims to characterize the effects of maternal hypoxia-induced IUGR on the lung proteome and identify key altered pathways relevant to asthma development in male and female adult offspring.