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Lack of small colony variants of Staphylococcus aureus from lower respiratory tract specimens

Lack of small colony variants of Staphylococcus aureus from lower respiratory tract specimens Abstract Background: Small-colony variants (SCVs) of

Hypoxia and sterile inflammation in cystic fibrosis airways mechanisms and potential therapies

Hypoxia and sterile inflammation in cystic fibrosis airways mechanisms and potential therapies ABSTRACT Cystic fibrosis is one of the most common

Clinical utility of surveillance computed tomography scans in infants with cystic fibrosis

Clinical utility of surveillance computed tomography scans in infants with cystic fibrosis Abstract Background: In cystic fibrosis (CF), irreversible

Research

BAL Inflammatory Markers Can Predict Pulmonary Exacerbations in Children With Cystic Fibrosis

Pulmonary exacerbations in cystic fibrosis are characterized by airway inflammation and may cause irreversible lung damage. Early identification of such exacerbations may facilitate early initiation of treatment, thereby potentially reducing long-term morbidity. Research question: Is it possible to predict pulmonary exacerbations in children with cystic fibrosis, using inflammatory markers obtained from BAL fluid?

Research

Lung inflammation and simulated airway resistance in infants with cystic fibrosis

Cystic fibrosis (CF) is characterized by small airway disease; but central airways may also be affected. We hypothesized that airway resistance estimated from computational fluid dynamic (CFD) methodology in infants with CF was higher than controls and that early airway inflammation in infants with CF is associated with airway resistance.

Research

Systems biology and bile acid signalling in microbiome-host interactions in the cystic fibrosis lung

The study of the respiratory microbiota has revealed that the lungs of healthy and diseased individuals harbour distinct microbial communities. Imbalances in these communities can contribute to the pathogenesis of lung disease. How these imbalances occur and establish is largely unknown. This review is focused on the genetically inherited condition of Cystic Fibrosis.

Early disease surveillance in young children with cystic fibrosis: A qualitative analysis of parent experiences

Early disease surveillance in young children with cystic fibrosis: A qualitative analysis of parent experiences Sensitive measures of early lung

Cystic Fibrosis Clinical Isolates of Aspergillus fumigatus Induce Similar Muco-inflammatory Responses in Primary Airway Epithelial Cells

Ivacaftor and Airway Inflammation in Preschool Children with Cystic Fibrosis

Ivacaftor and Airway Inflammation in Preschool Children with Cystic Fibrosis Authors: Paul McNally, Daryl Butler, Yuliya Karpievitch , Barry Linnane,

Bile Acid Signal Molecules Associate Temporally with Respiratory Inflammation and Microbiome Signatures in Clinically Stable Cystic Fibrosis Patients

Bile Acid Signal Molecules Associate Temporally with Respiratory Inflammation and Microbiome Signatures in Clinically Stable Cystic Fibrosis