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Network analysis of immunotherapy-induced regressing tumours identifies novel synergistic drug combinationsCancer immunotherapy has shown impressive results, but most patients do not respond.
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Relapse and outcome patterns of patients with central nervous system mixed malignant germ cell tumors treated without irradiationThis study investigated the relapse and outcome patterns of patients with central nervous system mixed malignant germ cell tumors treated with chemotherapy-only
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A CHAF1B-Dependent Molecular Switch in Hematopoiesis and Leukemia PathogenesisHere we report that CHAF1B is required for normal hematopoiesis while its overexpression promotes leukemia
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Functional genomics in cancer immunotherapy: Computational approaches for biomarker and drug discoveryThis review explores computational strategies to yield biological insight into the processes involved in the immunotherapeutic response
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Recurrent MET fusion genes represent a drug target in pediatric glioblastomaWe identified previously unidentified gene fusions involving the MET oncogene in pediatric glioblastoma
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The evolution of clinical trials for infant acute lymphoblastic leukemiaDespite initial improvements in survival of infants with ALL since establishment of the first pediatric cooperative group ALL trials, the poor outcome has...
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Statistical adjustment of genotyping error in a case-control study of childhood leukaemiaGenotyping has become more cost-effective and less invasive with the use of buccal cell...
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Fusionfinder: A software tool to identify expressed gene fusion candidates from RNA-seq dataThe hallmarks of many haematological malignancies and solid tumours are chromosomal translocations, which may lead to gene fusions.
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Identification of suitable endogenous control genes for microRNA expression profiling of childhood medulloblastoma and human neural stem cellsMedulloblastoma (MB) is the most common type of malignant childhood brain tumour.
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Efficacy of acute myeloid leukemia therapy without stem-cell transplantation in a child with blastic plasmacytoid dendritic cell neoplasmOur case demonstrates that AML therapy, without HSCT, can be sufficient to treat this rare disease in children.