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An in-depth investigation of gene regulation and cell populations at sites of fetal blood-cell production provides clues as to why children with Down’s syndrome are predisposed to developing leukaemia.
T cells engineered to express chimeric-antigen receptors (CAR-T cells) can effectively control relapsed and refractory haematological malignancies in the clinic. However, the successes of CAR-T cell therapy have not been recapitulated in solid tumours due to a range of barriers such as immunosuppression, poor infiltration, and tumour heterogeneity.
One of the researchers who helped crack the code of 10-year-old Northam girl Charlotte Patterson’s incredibly rare disease has received State Government funding that will allow her to use the same methods to rapidly assess the cases of hundreds more patients living with undiagnosed disease.
A cancer diagnosis in adolescents and young adults conferred substantial survival decrement.
The aetiology of childhood brain tumours (CBT) is largely unknown.
Rare childhood cancers have not benefited to the same extent from the gains that have been made for their frequently occurring counterparts.
Medulloblastoma, the most common pediatric malignant brain tumor, consists of at least four distinct molecular subgroups.
We examined the association of insight and grey matter volume using a voxel-based morphometry approach in volunteers with and without mild cognitive impairment.
Cancer immunotherapy has shown impressive results, but most patients do not respond.
Parental occupational exposure to engine exhausts and childhood brain tumors.