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Type 1 diabetes in pregnancy is associated with distinct changes in the composition and function of the gut microbiomeThe gut microbiome changes in response to a range of environmental conditions, life events and disease states. Pregnancy is a natural life event that involves major physiological adaptation yet studies of the microbiome in pregnancy are limited and their findings inconsistent. Pregnancy with type 1 diabetes (T1D) is associated with increased maternal and fetal risks but the gut microbiome in this context has not been characterized. By whole metagenome sequencing, we defined the taxonomic composition and function of the gut bacterial microbiome across 70 pregnancies, 36 in women with T1D.
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Birth order and childhood type 1 diabetes risk: A pooled analysis of 31 observational studiesBackground: The incidence rates of childhood onset type 1 diabetes are almost universally increasing across the globe but the aetiology of the disease...
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Improving epinephrine responses in hypoglycemia unawareness with real-time continuous glucoseThe objective of this study was to determine whether real-time continuous glucose monitoring (CGM) with preset alarms at specific glucose levels would prove...
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Effect of short-term use of a continuous glucose monitoring system with a real-timeThe objective of this study was to examine whether setting the low glucose alarm of a Guardian® REAL-Time continuous glucose monitoring system (CGMS) to 80 mg/d
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Contribution of an intrinsic lag of continuous glucose monitoring systems to differences in measured and actual glucose concentrationsCurrent continuous glucose monitoring (CGM) systems measure glucose levels in the interstitial fluid to estimate blood glucose concentration.
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Type 1 diabetes in children - emergency managementFifteen to sixty-seven percent of patients with new onset type 1 diabetes mellitus (T1DM) present in diabetic ketoacidosis (DKA), of which approximately...
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Birthweight and the risk of childhood-onset type 1 diabetesWe investigated whether children who are heavier at birth have an increased risk of type 1 diabetes
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Hypoglycemia alarm enhancement using data fusionThe acceptance of closed-loop blood glucose (BG) control using continuous glucose monitoring systems (CGMS) is likely to improve.
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Clinical evaluation of a noninvasive alarm system for nocturnal hypoglycemiaThe aim of this study was to evaluate the performance of a prototype noninvasive alarm system (HypoMon) for the detection of nocturnal hypoglycemia.
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Perinatal risk factors for childhood Type 1 diabetes in Western Australia - a population-based study (1980-2002)To investigate perinatal risk factors for childhood Type 1 diabetes in Western Australia, using a complete population-based cohort.