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Immunogenicity and Safety of a 2 + 1 DTPa Priming Schedule in Australian Infants and the Impact of Maternally Derived Antibodies on Pertussis Antibody Responses up to 4 Years of AgeWe assessed the impact of maternally derived pertussis antibodies on infant responses to a 2 + 1 vaccine schedule (6 weeks, 12 weeks, and 12 months). Infants with baseline antibodies showed lower IgG responses following the primary vaccination series, but this did not impair booster responses at 4 years of age.
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Coupling of response biomarkers between tumor and peripheral blood in patients undergoing chemoimmunotherapyPlatinum-based chemotherapy in combination with anti-PD-L1 antibodies has shown promising results in mesothelioma. However, the immunological mechanisms underlying its efficacy are not well understood and there are no predictive biomarkers to guide treatment decisions.
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Anaphylactic Reactions During Bee Venom Immunotherapy in the Paediatric PopulationA retrospective study will review episodes of anaphylaxis during bee venom immunotherapy in children, any modifications made to the dosing schedule, and the subsequent outcomes over a nine-year period in Western Australia.
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High prevalence of undiagnosed obstructive sleep apnoea in the general population and methods for screening for representative controlsUndiagnosed obstructive sleep apnoea (OSA) in the community makes comparisons of OSA subjects with control samples from the general population problematic.
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Early infant feeding and adiposity risk: from infancy to adulthoodIn our study, we aimed to examine early infant feeding and adiposity risk in a longitudinal cohort from birth to young adulthood using new as well as...
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Parental prenatal smoking and risk of childhood Acute Lymphoblastic LeukemiaThe association between parental smoking and risk of childhood acute lymphoblastic leukemia (ALL) was investigated in an Australian population-based...
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Emergency department overcrowding, mortality and the 4-hour rule in Western AustraliaThe objective of this study was to assess whether emergency department (ED) overcrowding was reduced after the introduction of the 4-hour rule in WA hospitals.
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DataSHIELD: taking the analysis to the data, not the data to the analysisDataSHIELD provides a novel technological solution that can facilitate the access of researchers and other healthcare professionals to individual-level data
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Optimization is required when using linked hospital and laboratory data to investigate respiratory infectionsDespite a recommendation for microbiological testing, only 45% of children hospitalized for respiratory infections in our previous data linkage study linked...
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Delivery at 37 weeks' gestation is associated with a higher risk for child behavioural problemsWe suggest that 37 weeks' gestation may not be the optimal cutoff for defining perinatal risk as it applies to behavioural development.