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Genetic and functional evaluation of the role of CXCR1 and CXCR2 in susceptibility to visceral leishmaniasis in north-east IndiaIL8RA and IL8RB, encoded by CXCR1 and CXCR2, are receptors for interleukin (IL)-8 and other CXC chemokines involved in chemotaxis and activation of...
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A "Candidate-Interactome" Aggregate Analysis of Genome-Wide Association Data in Multiple SclerosisThe interaction between genotype and Epstein Barr virus emerges as relevant for multiple sclerosis etiology.
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Human genetics of leishmania infectionsGWAS results provide firm confirmation for the importance of antigen presentation and the regulation of IFNγ in determining the outcome of Leishmania infections
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Comparative analyses of whole genome sequences of Leishmania infantum isolates from humans and dogs in northeastern BrazilOverall the analyses do not suggest individual sequence variants account for differences in clinical outcome or adaptation to different hosts.
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TLR1/2 activation during Heterologous prime-boost vaccination (DNA-MVA) enhances CD8+ T cell responses providingLeishmania (Viannia) parasites present particular challenges, as human and murine immune responses to infection are distinct from other Leishmania species
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Common variants near ATM are associated with glycemic response to metformin in type 2 diabetesMetformin is the most commonly used pharmacological therapy for type 2 diabetes. We report a genome-wide association study for glycemic response to metformin...
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Interleukin 10 gene polymorphisms and development of post kala-azar dermal leishmaniasis in a selected sudanese populationPost kala-azar dermal leishmaniasis (PKDL) is a cutaneous form of disease that develops at variable times after individuals have received treatment.
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Influence of Toxoplasma gondii on host cell functionToxoplasma gondii is a ubiquitous pathogen capable of infecting animals, including humans, & is a significant health burden in developed/developing countries
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Comparison of Methods to Account for Relatedness in Genome-Wide Association Studies with Family-Based DataHere we compare the performance of several LMM approaches (and software implementations, including EMMAX, GenABEL, FaST-LMM, Mendel, GEMMA and MMM) via their...
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Genetic and functional evidence for a locus controlling otitis media at chromosome 10q26.3Otitis media (OM) is a common childhood disease characterised by middle ear effusion and inflammation.