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A pilot study into assessing the danger of heated-tobacco-products

Alexander Anthony Dr Katherine Larcombe Kicic Landwehr BScEnv (Hons) PhD BSc (Hons) PhD BSc(Hons) Honorary Research Fellow Head, Airway Epithelial

Chronic carbon dioxide exposure: an unrecognised health risk of climate change?

Alexander Larcombe BScEnv (Hons) PhD Honorary Research Fellow Honorary Research Fellow Associate Professor Alexander Larcombe began work at The Kids

The health effects of electronic cigarettes

Alexander Larcombe BScEnv (Hons) PhD Honorary Research Fellow Honorary Research Fellow Associate Professor Alexander Larcombe began work at The Kids

Understanding how viral infection in early life impacts on lung function in adulthood

Alexander David Deborah Larcombe Martino Strickland BScEnv (Hons) PhD BSc PhD PhD Honorary Research Fellow Head, Chronic Diseases Research Head,

Quantifying airway remodelling for research or clinical purposes: How should we normalize for airway size?

Citation: Donovan GM, Wang KCW, Elliot JG, James AL, Noble PB. Quantifying airway remodelling for research or clinical purposes: How should we

The effects of acamprosate on maternal and neonatal outcomes in a mouse model of alcohol use disorders

Despite the teratogenic effects of alcohol, little is known about the safety of pharmacotherapies such as acamprosate for the treatment of alcohol use disorders in pregnancy. The aims of this study were to investigate, in a mouse model, the effects of maternally administered acamprosate on maternal and neonatal health, offspring neurodevelopment and behaviour, as well as examine whether acamprosate reduces the neurological harm associated with alcohol consumption in pregnancy.

Comment on Karthikeyan et al. Concordance between In Vitro and In Vivo Relative Toxic Potencies of Diesel Exhaust Particles from Different Biodiesel Blends. Toxics 2024, 12, 290

Dr Katherine Alexander Landwehr Larcombe BSc(Hons) BScEnv (Hons) PhD Senior Research Officer Honorary Research Fellow Katherine.landwehr@

Partial amelioration of a chronic cigarette-smoke-induced phenotype in mice by switching to electronic cigarettes

Electronic cigarettes ("e-cigarettes") are often marketed as smoking cessation tools and are used by smokers to reduce/quit cigarette smoking. The objective of this study was to assess the health effects of switching to e-cigarettes after long-term smoking in a mouse model and compare these effects with continued smoking, or quitting entirely. 

In utero and early-life nitrate in drinking water impacts lung function of weanling rats

Consumption of nitrate in drinking water has previously been associated with a range of adverse health effects, including methemoglobinemia and potentially cancer. In animal models, it has been shown to impact respiratory structure and function, however, there is a paucity of data of the effects of in utero exposure on the respiratory health of offspring.

Toxicity of plastic diesel exhaust in primary human airway epithelial cell cultures

Plastic pyrolysis oil, which can be produced with similar properties as diesel fuel (plastic diesel), can be used as an alternative to mineral diesel (ULSD) to run a diesel engine. This presents a potential method for recycling waste plastic. Typically plastic diesel is blended with mineral diesel, and oxygenated fuel additives such as ethers added to improve resulting fuel properties.