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Functional differences in airway dendritic cells determine susceptibility to IgE-sensitizationRespiratory IgE-sensitization to innocuous antigens increases the risk for developing diseases such as allergic asthma.
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CFTR-dependent defect in alternatively-activated macrophages in cystic fibrosisCFTR-dependent imbalance of macrophage phenotypes and functions could contribute to the exaggerated inflammatory response seen in CF lung disease
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Differential gene network analysis for the identification of asthma-associated therapeutic targets in allergen-specific T-helper memory responsesDifferential network analysis of allergen-induced CD4 T cell responses can unmask covert disease-associated genes and pin point novel therapeutic targets
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Personalized transcriptomics reveals heterogeneous immunophenotypes in children with viral bronchiolitisDysregulated expression of IFN-dependent pathways after respiratory viral infections is a defining immunophenotypic feature of AVB-susceptible infants
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Serum 25-hydroxyvitamin D concentrations and cardiometabolic risk factors in adolescents and young adultsAssociations between serum 25(OH)D concentrations and cardiometabolic risk factors from adolescence to young adulthood in the Raine Study
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The WHF Roadmap for Reducing CV Morbidity and Mortality Through Prevention and Control of Rheumatic Heart DiseaseAs a general guide, the Roadmap is meant to serve as the foundation for the development of tailored plans of action to improve RHD control in specific contexts.
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Prevention of Allergy/Asthma - New StrategiesThis review focuses on the scientific rationale for early intervention aimed at asthma prophylaxis and discusses therapeutic approaches
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Whole-Cell Pertussis Vaccination and Decreased Risk of IgE-Mediated Food Allergy: A Nested Case-Control StudyAustralian infants who received whole-cell pertussis vaccines were less likely to be diagnosed with food allergy in childhood
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A marked shift in innate and adaptive immune response in chinese immigrants living in a western environmentThere is a marked shift in innate and adaptive immune responses in Chinese immigrants after living in a Western environment for several years
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Prevention - what is the most promising approach?This paper is an editorial comment by Professor Patrick Holt on the potential for developing early intervention strategies in children with allergies and asthma