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Plasma Metabolite Profiles of Children with Autism Spectrum Disorder

Autism spectrum disorder (ASD), a neurodevelopmental condition characterised by social and communication differences, is complex and aetiologically heterogeneous. Untargeted metabolomics is emerging as a tool in screening for biochemical abnormalities. This research was conducted using the Australian Autism Biobank resource and involved analysis of plasma metabolites to characterise metabolite differences between autistic children and controls.

Citation:
Mullin BH, Stuckey M, Brown SJ, ……. Whitehouse AJO, Wilson SG. Plasma Metabolite Profiles of Children with Autism Spectrum Disorder. Metabolites. 2025;15(12).

Keywords:
Autism; autism spectrum disorder; metabolomics; restricted and repetitive behaviours and interests

Abstract:
Autism spectrum disorder (ASD), a neurodevelopmental condition characterised by social and communication differences, is complex and aetiologically heterogeneous. Untargeted metabolomics is emerging as a tool in screening for biochemical abnormalities. This research was conducted using the Australian Autism Biobank resource and involved analysis of plasma metabolites to characterise metabolite differences between autistic children and controls.