A New Model to Investigate the Action of Radiation and Cigarette Smoke on Head and Neck Cancer Cells

Smokers are at an increased risk of developing mucosal head and neck squamous cell cancers (HNSCCs) and have a worse prognosis when treated. The cellular and molecular mechanisms underlying the latter has not been established. We therefore developed an in vitro model to investigate the effects of radiation and smoking on mucosal HNSCCs.

Citation:
Floro KL, Gillman R, Wankell M, Dewdney B, Chilkuri M, et al. A New Model to Investigate the Action of Radiation and Cigarette Smoke on Head and Neck Cancer Cells. Cancers. 2025;17(8).

Keywords:
Head and neck cancer; radiation; smoking

Abstract:
Smokers are at an increased risk of developing mucosal head and neck squamous cell cancers (HNSCCs) and have a worse prognosis when treated. The cellular and molecular mechanisms underlying the latter has not been established. We therefore developed an in vitro model to investigate the effects of radiation and smoking on mucosal HNSCCs.